解剖学报

›› 2012, Vol. 43 ›› Issue (5): 658-661.doi: 10.3969/j.issn.0529-1356.2012.05.014

• 组织学胚胎学发育生物学 • 上一篇    下一篇

Bcl-2在小鼠肾脏发生发育中的表达

宋小峰1,2; 陈雪1; 任昊1; 翟效月1*   

  1. 1.中国医科大学组织学与胚胎学教研室，沈阳 110001; 2.辽宁医学院组织学与胚胎学教研室，辽宁 锦州 121001
  • 收稿日期:2011-10-23 修回日期:2011-11-14 出版日期:2012-10-06
  • 通讯作者: 翟效月

Expression of Bcl-2 during the development of mouse kidney

  1. 1.Department of Histology and Embryology,China Medical University, Shenyang 110001,China;(2.Department of Histology and Embryology, Liaoning Medical College, Liaoning Jinzhou 121001, China
  • Received:2011-10-23 Revised:2011-11-14 Online:2012-10-06
  • Contact: ZHAI Xiao-yue

关键词: Bcl-2, 近端小管, 发育, 树脂切片, 免疫组织化学, 免疫荧光, 小鼠

Abstract: Objective To explore the expression of Bcl-2 during mouse kidney development. Methods Fifty-five Kunming mice from embryonic day 16(E16d), 18 and postnatal day 1(P1d), 3, 5, 7, 14, 21 were chosen to be used to investigate the expression of Bcl-2 on epoxy sections with immunohistochemistry technique and stereological methods. Results During mouse kidney development, the positive staining of Bcl-2 was mainly observed in proximal tubules. The increase with numerical area density(N A) of Bcl-2 was the fastest from E18d to P1d, while not much changed after P7 d. Conclusion During the pristine kidney development, the expression of Bcl-2 influences survival or death of proximal tubule.

Key words: Bcl-2, Proximaltubule, Development, Epoxysection, Immunohistochemistry, Immunofluorescence, Mouse

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